Marked differences in differentiation propensity among human embryonic stem cell lines
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- 17 February 2008
- journal article
- research article
- Published by Springer Nature in Nature Biotechnology
- Vol. 26 (3) , 313-315
- https://doi.org/10.1038/nbt1383
Abstract
The differentiation potential of 17 human embryonic stem (hES) cell lines was compared. Some lines exhibit a marked propensity to differentiate into specific lineages, often with >100-fold differences in lineage-specific gene expression. For example, HUES 8 is best for pancreatic differentiation and HUES 3 for cardiomyocyte generation. These non-trivial differences in developmental potential among hES cell lines point to the importance of screening and deriving lines for lineage-specific differentiation.Keywords
This publication has 15 references indexed in Scilit:
- Reprogramming somatic cells towards pluripotency by defined factorsCurrent Opinion in Biotechnology, 2007
- Characterization of human embryonic stem cell lines by the International Stem Cell InitiativeNature Biotechnology, 2007
- A gut feelingNature Biotechnology, 2005
- Efficient differentiation of human embryonic stem cells to definitive endodermNature Biotechnology, 2005
- Derivation of Embryonic Stem-Cell Lines from Human BlastocystsNew England Journal of Medicine, 2004
- CD45: A Critical Regulator of Signaling Thresholds in Immune CellsAnnual Review of Immunology, 2003
- Embryo-Derived Stem Cells: Of Mice and MenAnnual Review of Cell and Developmental Biology, 2001
- Troponin I isoform expression is developmentally regulated in differentiating embryonic stem cell-derived cardiac myocytesDevelopmental Dynamics, 1996
- Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.Genes & Development, 1995
- Lessons from the repression of the α-fetoprotein gene in the adult liverHepatology, 1993