A HTLV-I Carrier Who Showed Various Symptoms and Antibodies of Autoimmune Diseases.
- 1 January 1993
- journal article
- case report
- Published by Japanese Society of Internal Medicine in Internal Medicine
- Vol. 32 (6) , 449-454
- https://doi.org/10.2169/internalmedicine.32.449
Abstract
We report a 37-year-old female HTLV-I carrier with complicating primary biliary cirrhosis (PBC) and mixed connective tissue disease (MCTD). Serum anti-HTLV-I antibody titer was x256. Flower cells (4.5%) were found in the peripheral blood. Southern blot analysis showed no clonal integration in peripheral blood lymphocyte (PBL) DNA. Polymerase chain reaction showed the HTLV-I genome in PBL DNA. As cholestatic liver dysfunction and serum titer of anti-mitochondrial antibody were found, a clinical diagnosis of PBC was made. This patient later developed MCTD. These diseases responded well to prednisone. The pathogenetic relationship of HTLV-I infection with various autoimmune diseases is discussed.Keywords
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