Intrathecal Morphine Dose-Response Data for Pain Relief After Cholecystectomy

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Abstract
(0.12 mg), 7 (0.15 mg), and 8 (0.20 mg). Preservative-free morphine hydrochloride mixed in hyperbaric tetracaine solution was administered at the time of induction of spinal anesthesia just before surgery. Pain relief was significantly greater for the first 24 h in groups 3, 4, 5, 6, 7, and 8 than in group 1. The incidence of respiratory depression was significantly greater in groups 7 and 8 than in the other groups in the first 48 h. Vomiting occurred significantly more often in group 1 than in groups 2, 3, 4, and 5. Intraoperative cholangiography and the postoperative clinical course indicated no increase in tone of the sphincter of Oddi in any patient. We conclude that 0.06–0.12-mg intrathecal morphine is the best dose range for pain relief after cholecystectomy without respiratory depression and with the lowest incidence of vomiting or pruritus, or both. Address correspondence to Dr. Watanabe, Department of Anesthesia, Mito Saiseikai General Hospital, 3–3–10, Futabadai, Mito City, Ibaraki, 311–41, Japan. Accepted for publication October 12, 1989. © 1990 International Anesthesia Research Society...