Prophylaxis and Treatment of Anaerobic Infections following Caesarean Section with Tinidazole

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Abstract
The purpose of this prospective, double-blind, placebo-controlled study was to clarify the effect of a single i.v. infusion of 500 mg of tinidazole on infections that followed a cesarean section. Eighty consecutive cesarean-section patients and thereafter 72 women undergoing non-elective cesarean section were randomly assigned to 2 groups, each receiving i.v. infusions at cord clamping. In the entire sample the incidence of endometritis wound infection in the placebo group was 27.3% (21/77) vs. 10.7% (8/75) in the tinidazole group (P < 0.01). In the non-elective cesarean-section group the incidence of endometritis/wound infection was 39.6% (21/53) in the placebo group vs. 14.3% (7/49) in the tinidazole group (P < 0.01). Twenty-seven positive bacterial cultures [Peptococcus, Peptostreptococcus, Clostridium, Bacteroides fragilis, B. melaninogenicus, Fusobacterium, Gardnerella vaginalis, Staphylococcus, .beta.-hemolytic streptoccocus, Escherichia coli and Enterococcus] yielded a pure anaerobic growth in 59% (16/27) of cases, of which 87.5% (14/16) were treated successfully with oral tinidazole.