EXPERIMENTAL PANCREATOLITHIASIS IN THE DOG

  • 1 January 1981
    • journal article
    • research article
    • Vol. 89  (6) , 687-691
Abstract
A model is examined in which partial or complete pancreatic duct obstruction was surgically created in dogs. Pancreatic calculi were demonstrated in 46.7% of the dogs (14 of 30) with partial outflow obstruction for 4 mo. or longer. No pancreatic calculi were found in any of the dogs with complete pancreatic duct obstruction. All calculi produced were localized in the ductal system. The organic and inorganic composition of canine and human pancreatic calculi were quite similar. Connective tissue proliferation and mucous cell metaplasia of the ductal epithelium, often seen in association with clinical pancreatolithiasis, are also detected in the pancreata of dogs that had partial obstruction of pancreatic excretion. An experimental model of pancreatolithiasis may be accomplished in dogs by the partial obstruction of pancreatic excretion.

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