Effects of chlorimipramine on human cells in tissue culture.

  • 1 October 1970
    • journal article
    • Vol. 51  (5) , 507-11
Abstract
Chlorimipramine is toxic to human skin fibroblasts in culture at concentrations as low as 10 μg./ml. if treatment exceeds 1 hr. The effects are manifest in arrest of mitosis at metaphase and subsequent cell death. The drug inhibits oxygen uptake by cells in an oxygen electrode system, suggesting that the drug acts primarily in restricting energy metabolism. This is substantiated by the finding that ATP can reverse inhibitory effects in the cultures to some extent.

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