Hyper‐interleukin (IL)‐6‐naemia in haemophagocytic lymphohistiocytosis

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Abstract
Clinical features in patients with haemophagocytic lymphohistiocytosis (HLH) have been demonstrated to be characterized by hypercytokinaemia. Previously, we reported the impact of high serum levels of interferon (IFN)‐gamma and soluble IL‐2 receptor (sIL‐2R) on patient outcome; however, it was not known if serum levels of interleukin (IL)‐6 also could be a prognostic factor. In a study during the active phase of disease in 25 cases of HLH in children and young adults (median age 3 years, range 0.1–23 years), we noted 12 cases which showed serum IL‐6 >100 (normal 100 pg/ml and those with IL‐6 100 pg/ml), underlying disorders causing haemophagocytosis were found to be different between groups A and B.

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