The Neutralization of Transmissible Gastroenteritis Virus by Normal Heterotypic Serum
Open Access
- 1 February 1979
- journal article
- Published by Microbiology Society in Journal of General Virology
- Vol. 42 (2) , 279-287
- https://doi.org/10.1099/0022-1317-42-2-279
Abstract
Exposure of transmissible gastroenteritis virus of pigs to unheated normal heterotypic serum resulted in a drop in infectivity, an effect which was lost after heating the serum to 56 °C for 30 min or by treatments inactivating complement. Analysis of virus proteins, RNA and lipids, and centrifugation studies showed little difference between inactivated and control virus, but electron microscopy of negatively stained particles after treatment with serum revealed holes in the virus envelope, characteristic of those caused by complement in the presence of antibody.Keywords
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