s-Triazolopyrimidines. Part IV. Synthesis as potential therapeutic agents
- 1 January 1966
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society C: Organic
- Vol. 22, 2031-2038
- https://doi.org/10.1039/j39660002031
Abstract
The interaction of cyanogen chloride and 2-hydrazinopyrimidines under mild conditions yields 3-amino-s-triazolo-[4,3-a]pyrimidines, which are isomerised under suitable conditions to the corresponding 2-amino-s-triazolo-[2,3-a]pyrimidines. The mechanisms involved have in part been elucidated starting from 2-hydrazino-pyrimidines with alkoxyl groups in position 4 and/or 6.Keywords
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