15Chromium-Release Microassay Technique for Cell-Mediated Immunity to Mumps Virus: Correlation with Humoral and Delayed-Type Skin Hypersensitivity Responses
- 1 December 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 134 (6) , 546-551
- https://doi.org/10.1093/infdis/134.6.546
Abstract
Lymphocyte-mediated immune responsiveness to mumps virus was studied with use of a 51chromium (51Cr)-re1ease microassay of Iymphocytotoxicity to target cells persistently infected with mumps virus. The release of 51Cr from immune cells was found to be virus-specific and reproducible and correlated well with the presence of antibody but not with the magnitude of antibody levels. Delayed-type skin hypersensitivity and specific immune release of 15Cr did not correlate well, which suggests that the two events may be mediated by different populations of cells.Keywords
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