Efficient Lipase-catalyzed Enantioselective Acylation under Reduced Pressure Conditions in an Ionic Liquid Solvent System
- 1 February 2002
- journal article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 31 (2) , 154-155
- https://doi.org/10.1246/cl.2002.154
Abstract
Lipase-catalyzed transesterification was demonstrated using methyl esters as acyl donors under reduced pressure in an ionic liquid ([bmim]PF6) solvent system. The transesterification of 5-phenyl-1-penten-3-ol took place smoothly under reduced pressure at 27 hPa at 40 °C when methyl phenylthioacetate was used as acyl donor in [bmim]PF6, and we succeeded in obtaining the corresponding acylated compound in optically pure form; this makes it possible to use lipase repeatedly because there was no drop in the reaction rate despite three repetitions of the process.This publication has 12 references indexed in Scilit:
- Improved Preparation and Use of Room-Temperature Ionic Liquids in Lipase-Catalyzed Enantio- and Regioselective AcylationsThe Journal of Organic Chemistry, 2001
- Immobilized baker's yeast reduction of ketones in an ionic liquid, [bmim]PF6 and water mixTetrahedron Letters, 2001
- A Highly Chemo- and Stereoselective Synthesis of β-Keto Esters via a Polymer-Supported Lipase Catalyzed TransesterficationThe Journal of Organic Chemistry, 2001
- Lipase-Catalyzed Reactions in Ionic LiquidsOrganic Letters, 2000
- Enzymatic Catalysis of Formation of Z-Aspartame in Ionic Liquid - An Alternative to Enzymatic Catalysis in Organic SolventsBiotechnology Progress, 2000
- Determination of the absolute configuration of partly fluorinated allylic alcohols; the first synthesis of optically pure 1,2-difluoroallylic alcoholsTetrahedron Letters, 2000
- Room-temperature ionic liquids as replacements for organic solvents in multiphase bioprocess operationsBiotechnology & Bioengineering, 2000
- Room-Temperature Ionic Liquids. Solvents for Synthesis and CatalysisChemical Reviews, 1999
- The generation of glyceryl ether lipids highly enriched with eicosapentaenoic acid and docosahexaenoic acid by lipaseTetrahedron Letters, 1994
- The preparation of homogeneous triglycerides of eicosapentaenoic acid and docosahexaenoic acid by lipaseTetrahedron Letters, 1993