Mannheimia ( Pasteurella ) haemolytica Leukotoxin Binding Domain Lies within Amino Acids 1 to 291 of Bovine CD18
Open Access
- 1 September 2005
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 73 (9) , 6179-6182
- https://doi.org/10.1128/iai.73.9.6179-6182.2005
Abstract
Previously, we identified bovine CD18 as the receptor for leukotoxin secreted by Mannheimia ( Pasteurella ) haemolytica . In this study, we constructed bovine-murine CD18 chimeras to locate the leukotoxin binding domain on CD18. Leukotoxin specifically lysed transfectants expressing bovine CD18 fragment encompassing amino acids 1 to 291, indicating that leukotoxin binding domain lies within amino acids 1 to 291 of bovine CD18.Keywords
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