EFFECTS OF THE INTRAVENOUS ADMINISTRATION OF GLYCEROL SOLUTIONS TO ANIMALS AND MAN1

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Abstract
The intravenous administration of glycerol solutions to rabbits, dogs and to humans causes no toxic or other undesirable effects. Human subjects received one liter of solution which contained 50 g of glycerol, 50 g of glucose and 9.0 g of NaCl. The rapid administration of solutions containing 20% or more of glycerol caused a transient drop in blood pressure in the dog; this effect is probably due to a peripheral vasodilating action. No hemoglobinuria was observed and only slight rises in plasma hemoglobin concentrations occurred. The results indicate that previously reported toxic and hemolytic effects ascribed to parenterally administered glycerol were due to osmotic disturbances produced by the injection of concentrated glycerol solutions.