Pancreatic Polypeptide Responses to a Meal and to Intraduodenal Amino Acids and Sodium Oleate*

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Abstract
Serum concentrations of immunoreactive pancreatic polypeptide (IR-PP) were measured in dogs in response to a meal and to intraduodenal infusions of amino acids, Na oleate and HCl. The effects of somatostatin on meal-stimulated IR-PP concentrations were studied. In response to a meal, IR-PP rose from 151 .+-. 19 pg/ml to 296 .+-. 35 pg/ml (P < 0.01) at 15 min, reached a plateau of 367 .+-. 56 pg/ml at 45 min and remained elevated for 4 h. In response to intraduodenal amino acids, IR-PP rose from 196 .+-. 22 pg/ml to 342 .+-. 19 pg/ml (P < 0.01), and serum alanine rose from 251 .+-. 18 mM to 361 .+-. 30 mM. Peak concentrations of IR-PP were reached before alanine rose above baseline. During administration of intraduodenal Na oleate, IR-PP rose from 181 .+-. 21 pg/ml to 348 .+-. 17 pg/ml (P < 0.01). Intraduodenal HCl had no effect on IR-PP. I.v. somatostatin (100 .mu.g/h) suppressed meal-stimulated IR-PP from 450 .+-. 68 pg/ml to 133 .+-. 23 pg/ml (P < 0.01). IR-PP is increased after a meal and intraduodenal administration of amino acids and Na oleate; the increases in serum IR-PP precede increases in serum levels of absorbed alanine; and somatostatin suppressed the meal-stimulated increase in serum IR-PP.