The Influence of Testicular Microanatomy on the Potential Genetic Dose from Internally Deposited 239 Pu Citrate in Chinese Hamster, Mouse, and Man
- 1 February 1979
- journal article
- research article
- Published by JSTOR in Radiation Research
- Vol. 77 (2) , 292-302
- https://doi.org/10.2307/3575141
Abstract
The localization, retention and microdistribution of 239Pu citrate in the testes of the Chinese hamster were determined. Testicular morphometric measurements were made in adult mice and Chinese hamsters as well as in aged, adult and immature humans. Calculations based on these morphometric measurements and a nonuniform microdistribution of Pu indicated that the radiation dose to spermatogonia of man was less than that predicted from a uniform distribution of activity. This contrasts with the enhanced dose to the spermatogonia in mouse and Chinese hamsters produced by the unique microanatomy and nonuniform deposition of Pu in the testes of rodents. Levels of 239Pu which induced marked life shortening and increased cancer incidence caused no significant increase in the frequency of mitotic chromosome aberrations in spermatogonia.This publication has 0 references indexed in Scilit: