Poor sulphoxidation ability in patients with food sensitivity.
- 9 July 1988
- Vol. 297 (6641) , 105-107
- https://doi.org/10.1136/bmj.297.6641.105
Abstract
Patients with well defined reactions to foods were examined for their ability to carry out both sulphur and carbon oxidation reactions by using carbocisteine and debrisoquine as probe compounds. The proportion of poor sulphoxidisers (58 of 74) was significantly greater than that of a previously determined normal control population (67 of 200; p less than 0.005). The proportion of poor carbon oxidisers was not significantly different from the controls. Metabolic defects may play a part in the pathogenesis of adverse reactions to foods.This publication has 10 references indexed in Scilit:
- IGE COMPLEXES IN FOOD ALLERGY1987
- Cytosolic sulphoxidation of S-carboxymethyl-L-cysteine in mammalsBiochemical Pharmacology, 1986
- Genetic aspects of the polymodally distributed sulphoxidation of S‐ carboxymethyl‐L‐cysteine in man.British Journal of Clinical Pharmacology, 1984
- Food hypersensitivityJournal of Allergy and Clinical Immunology, 1984
- The contribution of genetically determined oxidation status to inter‐ individual variation in phenacetin disposition.British Journal of Clinical Pharmacology, 1983
- SUBSTRATE-SPECIFICITY OF THE FORM OF CYTOCHROME-P-450 CATALYZING THE 4-HYDROXYLATION OF DEBRISOQUINE IN MAN1983
- Defective Oxidation of DrugsClinical Pharmacokinetics, 1982
- A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.Journal of Medical Genetics, 1980
- Contribution of Environmental Factors to Variability in Human Drug MetabolismDrug Metabolism Reviews, 1979
- Systemic allergic reactions to ingested antigensJournal of Allergy, 1969