Nephropathy in Sucrose-fed Rats: Electron and Light Microscopic Studies
- 1 December 1971
- journal article
- Published by American Diabetes Association in Diabetes
- Vol. 20 (12) , 803-810
- https://doi.org/10.2337/diab.20.12.803
Abstract
Diffuse intercapillary glomerulosclerosis and exudative glomerulosclerosis were produced in rats fed high-sucrose diet for periods of nine to eighteen months. These lesions were observed by light and electron miscroscopy. Impairment of glucose tolerance was observed in the sucrose-fed animals and marked proteinuria developed in the course of long-term sucrose feeding. Such lesions did not develop in a control group of age-matched fed high-starch diets.Keywords
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