Oxygen deficit in hemorrhagic shock in dogs

Publisher Website
Google Scholar
Abstract
Dogs anesthetized with morphine and pentobarbital were hemorrhaged to 30 or 40 mm Hg, and kept at this hypotensive level until 2-40% uptake of the maximum volume of shed blood occurred, at which time the shed blood was reinfused. The body temperature was maintained at either 39.0 [plus or minus] 0.6 standard deviation C or 36.7 [plus or minus] 1.1 C during hypotension. Oxygen deficit, calculated as the time integral of the difference between the average control O2 consumption and that during hypotension, showed no significant correlation with ultimate survival or the duration of survival. Neither the duration nor the level of hypotension, in the range used in these experiments, had significant bearing on survival; neither did atropinization just before reinfusion. Survival was related to percent uptake, and to arterial blood pressure and total body O2 consumption 1 hr after reinfusion. Although O2 deficits in certain vital tissues may be crucial to ultimate survival, cumulative total body O2 deficit is not an adequate measure of this deficiency except under special circumstances.

This publication has 1 reference indexed in Scilit: