HYPERPARATHYROIDISM

7 March 1931

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 96 (10) , 745-751
https://doi.org/10.1001/jama.1931.02720360015004

Abstract

It is well known that when parathyroid extract, the active principle of the parathyroid gland, is injected into an organism, hypercalcemia is produced. If these injections are continued a negative calcium balance results, with ultimate decalcification. This is followed by the formation of fibrous bone lesions, as Jaffe, Bodansky and Blair¹have recently shown. That a condition similar to this experimental hyperparathyroidism could exist clinically was not clearly recognized until Mandl²in 1926 removed a parathyroid tumor in a case of generalized osteitis fibrosa cystica and thereby effected a prompt and apparently permanent clinical improvement. This suggested that the causative factor of osteitis fibrosa cystica was a hyperactive parathyroid. The correctness of this conclusion has been fairly well established by a series of other cases reviewed by Barr and Bulger,³and correlated under the term "clinical hyperparathyroidism." In this paper we are presenting another case of osteitis

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