GROWTH STIMULATION OF CULTURED ENDOTHELIAL CELLS BY TUMOR-CELL HOMOGENATES

  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (9) , 3269-3273
Abstract
Short term cultures of endothelial cells from fetal bovine heart and aorta consistently display increased growth rates when crude tumor cell homogenates from the Walker 256 [rat] adenocarcinoma (ascites and solid forms as well as tumor cells from a suspension culture) are added to the culture media. The tumor-derived material produces growth stimulation in sparse and confluent endothelial cell cultures. Homogenates of embryonic tissues and cultured cells show similar growth-promoting effects. Corresponding material from various adult tissues is ineffective. The nonendothelial cells that were tested show no growth response or only a slight positive growth response to the tumor cell homogenates. The results indicate the feasibility of using this in vitro system as paradigm of the tumor-induced vascularization process.

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