Permeation of L-Proline in the Cestode, Hymenolepis diminuta

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Abstract
The uptake of L-proline in the rat cestode, Hymenolepis diminuta, follows adsorption kinetics. The transport system becomes partially saturated at 0.5 to 0.6 mM proline concentrations and fully so at 8 to 10 mM. Competition studies indicate that the efflux of proline is mediated, although it is a linear function of internal concentrations. A part of the exogenous proline pool becomes compartmentalized and is not available for efflux. Glucose does not influence the absorption of proline when present externally. However, high internal concentrations of glucose inhibit the uptake of proline and several other amino acids.