An enantiocontrolled synthesis of a key intermediate to (+)-lactacystin
- 1 January 1998
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 18,p. 1929-1930
- https://doi.org/10.1039/a804954h
Abstract
An asymmetric synthesis of a key intermediate 16 to (+)-lactacystin 1 has been established starting from epoxide 2 via intramolecular mercurioamidation of allylic trichloroacetimidate 4 and concomitant addition-reduction of ester 13 by Pri MgBr, in which reduction of the intermediate ketone proceeded with complete stereoselectivity.Keywords
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