ELECTROLYTE SOLUTION APPROXIMATING PLASMA CONCENTRATIONS

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Abstract
Recent studies have emphasized the desirability of maintaining normal levels of electrolytes and water in plasma and tissue cells. This is difficult to accomplish because the electrolyte composition of the primary replacement solutions generally available for parenteral therapy is significantly different from normal plasma. For example, 0.9% sodium chloride solution contains too much chloride but no bicarbonate and no potassium. Attempts were made, therefore, to devise a water solution of plasma electrolytes to correct most anomalies. Animal experiments were conducted to obtain the first approximations, and then the proposed solution was subjected to clinical trial. The results to date have been sufficiently encouraging to warrant this report of our observations. ANIMAL EXPERIMENTS Hemorrhage was investigated first because of its ubiquity and importance in medicine and surgery and its reproducibility in dogs. Massive volumes of blood were removed from unanesthetized dogs and concurrently replaced with an electrolyte solution.1During and after the
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