IMMUNO-CYTOCHEMICAL STUDIES OF APUD CELLS IN AIRWAYS - EFFECTS OF NITROSODIETHYLAMINE AND NITROGEN-DIOXIDE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 106  (8) , 400-403
Abstract
The amine precursor uptake and decarboxylase (APUD) cells and neuroepithelial bodies (NEB) in airways of adult rats were studied by immunocytochemical methods for the presence of ACTH, growth hormone (hGH), calcitonin and bombesin in control animals and following exposure to nitrosodiethylamine and NO2. Calcitonon-like immunoreactivity (CLIR) is present in APUD cells of the trachea and bronchioles and in NEB in the lung. Rats treated with nitrosodiethylamine and NO2 exhibit increased numbers of argyrophilic cells but no increase in cells containing specific intracytoplasmic CLIR. The presence of ACTH, hGH and bombesin in respiratory tract APUD cells was not observed. APUD cells in the trachea and bronchioles of adult rats apparently harbor endocrine cells with immunohistochemical characteristics similar to C cells of the thyroid, and these cells do not appear to be altered in number when rats are treated with agents known to produce an increase in APUD cells. [The APUD cells were implicated as the precursor cells of malignant neoplasms of the lung.].

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