The Response of Pancreatic and Pituitary Hormones to Pulses and Constant Infusion of Somatostatin

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Abstract
The inhibitory action of pulses and constant infusion of somatostatin on the secretion of pancreatic and pituitary hormones was studied serially in 7 normal men and 2 untreated acromegalies. In normal men, significant inhibition of basal release of insulin and glucagon was elicited by as little as 1 μg dose of a pulse of somatostatin. Increasing doses of somatostatin (5, 50, 250 and 500 μg) given as a single pulse at weekly intervals produced what appears to be a decreased inhibition of glucagon while no measurable relationship between the dose of somatostatin and the degree of inhibition of insulin was seen. Given during the same day, incremental doses (from L to 250 μg) of pulses of somatostatin produced a progressive decline in both glucagon and insulin. The elevated basal levels of GH, insulin and glucagon seen in acromegalies, were inhibited by a pulse of somatostatin as little as 2 μg. These inhibitions were sustained during the constant infusion of somatostatin (2.5 μg/min), and are bound in GH, insulin and glucagon appeared promptly following the infusion.

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