Metabolic and blood catecholamine responses to exercise during alkalosis

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Abstract
The effects of metabolic alkalosis on muscle lactate accumulation and plasma catecholamine concentrations were studied in six highly trained subjects during short-term ergocycle exercises to exhaustion (375 W). The studies were performed after oral administration of NaHCO3 (alkalosis) and CaCO3 (placebo). There was a significant increase in resting blood pH after NaHCO3 ingestion (7.35 .+-. 0.02) compared to placebo (7.27 .+-. 0.02). A longer endurance time was achieved during alkalosis (75.3 .+-. 8 s) than during control (61.5 .+-. 2 s), but similar blood pH and HCO3- levels were found at exhaustion in both treatments. Metabolic alkalosis resulted in higher elevation in muscle lactate concentration (31.7 .THETA. 4.6 mmol .cntdot. kg-1 wet weight) compared to control (17 .+-. 4 mmol .cntdot. kg-1 wet weight). Despite longer exercise duration in alkalosis plasma norepinephrine and epinephrine concentrations at exhaustion were reduced by 30 and 34%, respectively. These results indicate that alkalosis increased muscle lactate accumulation during exhaustive exercise. These changes were associated with a reduced blood catecholamine response to exercise.

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