Sensitivity of Neisseria meningitidis to Sulfonamides and Antibiotics

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Abstract
During the recent epidemic of meningitis in Brazil, 1974, bacteriological and antibiotic sensitivity investigations were performed on 302 strains of N. meningitidis, isolated from meningitis patients from the Sao Paulo and Rio de Janeiro districts in the 1st half of 1974. The experiments showed that 58% of the strains belong to the serological type A, 25% belong to type C and the remaining 17% to a group designated untypable in that they did not react with the diagnostic antisera A, B, C and D. Antibiotic sensitivity tests in vitro showed that, independently of the serological type, 89.8% of the 302 strains were inhibited by 10 .mu.g/ml of a long-acting sulfonamide (sulfamethoxypyrazine, SMP), that is, by levels easily reached in the CSF during a normal prophylactic or therapeutic treatment.

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