ANALYSIS OF THE TISSUE AND CELLULAR-LOCALIZATION OF ALPHA-1-ANTICHYMOTRYPSIN BY AN IMMUNOHISTOCHEMICAL TECHNIQUE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 73  (5) , 742-747
Abstract
The cellular localization of .alpha.-1-antichymotrypsin (.alpha.1-ACT) was studied immunohistochemically using rabbit horseradish peroxidase-labeled Fab'' against human .alpha.1-ACT. .alpha.1-ACT was found in cell nuclei of carcinomas of the stomach, liver, breast, pancreas and leiomyosarcoma and in cell nuclei of lymphoid cells infiltrated into the stomach carcinoma mass. .alpha.1-ACT was not found in carcinoma cells of the colon, uterus, rectum or esophagus, or in lymphoid cells infiltrated into the rectal carcinoma mass or into inflammatory regions such as gastric ulcers or appendicitis. .alpha.1-ACT was not found in normal cells around the carcinoma mass or in normal tissues.

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