Effect of dexamethasone on protein extravasation in the brain in acute hypertension induced by amphetamine
- 29 January 2009
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 57 (2) , 180-185
- https://doi.org/10.1111/j.1600-0404.1978.tb02835.x
Abstract
Amphetamine produces protein leakage in the brain when given to rats under nitrous oxide anesthesia. The blood-brain barrier dysfunction is caused by the combined effect of blood pressure increase and vasodilatation. In the present experiments pretreatment with dexamethasone, 2 mg .cntdot. kg-1, diminished the amphetamine-induced extravasation of Evans blue albumin and 125IHSA [human serum albumin] in the rats'' brain. Possible explanations of the effect of dexamethasone on cerebrovascular permeability are discussed.This publication has 21 references indexed in Scilit:
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