Azelaic and pimelic acids: Metabolic intermediates or artefacts?
- 22 July 1991
- journal article
- research article
- Published by Wiley in Journal of Inherited Metabolic Disease
- Vol. 15 (2) , 220-223
- https://doi.org/10.1007/bf01799635
Abstract
Azelaic and pimelic acids are excreted in elevated amounts in urine in disorders of mitochondrial β-oxidation and disorders of peroxisomal β-oxidation, for which they are of significant diagnostic value. We have detected the presence of azelaic, pimelic and even-chain-length dicarboxylic acids (adipic, suberic and sebacic acids) arising artefactually as a result of storage of small sample volumes in plastic containers. Storage of samples for organic acid analysis in glass containers is recommended.Keywords
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