Treatment of Acne Vulgaris

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Abstract
The authors have studied the effectiveness of selected orally administered antibiotics and sulfonamides in treating certain moderately severe to very severe forms of acne. All patients had failed to respond satisfactorily to other measures. However, the systemic antibacterial agents were used as supplementary, rather than substitute, methods of therapy. Evaluation is made of the nature and degree of side-effects of long-term and short-term use of these drugs. There were 312 courses of oral therapy administered from 2 days to 6 years 9 months to 208 patients. The results were excellent in 13 of the courses, good in 196, fair in 86 and poor in 17. Side-effects included Candida albicans vaginitis (the only severe complication requiring therapy), diarrhea, mild nausea, and changes of total or differential white blood cell count. Only 27 patients had complaints which necessitated the discontinuation of the drug used.

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