Monoclonal anti-Fc receptor IgG blocks antibody enhancement of viral replication in macrophages
- 1 January 1981
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 289 (5794) , 189-191
- https://doi.org/10.1038/289189a0
Abstract
West Nile virus (WNV) replication in the P388 D1 macrophage cell line provides a reproducible model system for studying ADE [antibody-dependent enhancement] of viral replication. Mouse macrophages have 2 FcR[Fc receptor]FcRI, which is trypsin-sensitive and binds IgG2a, and FcRII, which is trypsin-resistant and binds IgG2b and IgG1 complexes. The FcR was purified using rat anti-mouse FcRmonoclonal antibody which blocks FcRII. Anti-FcR IgG and its Fab fragment block ADE of virus replication by anti-WNV monoclonal antibodies.This publication has 10 references indexed in Scilit:
- Purificaton of a functional mouse Fc receptor through the use of a monoclonal antibody.The Journal of Experimental Medicine, 1980
- Cross‐protection and cross‐reactive cytotoxic T cells induced by influenza virus vaccines in miceEuropean Journal of Immunology, 1980
- Antibody-mediated enhancement of Flavivirus replication in macrophage-like cell linesNature, 1979
- In Vivo Enhancement of Dengue Virus Infection in Rhesus Monkeys by Passively Transferred AntibodyThe Journal of Infectious Diseases, 1979
- Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.The Journal of Experimental Medicine, 1979
- The Fc Receptors of Primary and Cultured Phagocytic Cells Studied with Homogeneous AntibodiesThe Journal of Immunology, 1978
- Biologic and Biochemical Activities of Continuous Macrophage Cell Lines P388D1 and J774.1The Journal of Immunology, 1977
- Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibodyThe Journal of Experimental Medicine, 1977
- Antibodies to major histocompatibility antigens produced by hybrid cell linesNature, 1977
- Comparison of Direct and Indirect Solid-Phase Microradioimmunoassays for the Detection of Viral Antigens and Antiviral AntibodyApplied Microbiology, 1973