Induced Synthesis of Histamine, Microcirculatory Regulation and the Mechanism of Action of the Adrenal Glucocorticoid Hormones

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Abstract
A new concept of histamine mobilization, new synthesis at variable rates, catalyzed by an inducible form of histidine decarboxylase, is discussed. Induced histamine seems to be the intrinsic regulator of the autonomous changes of the microcirculation, normally involved in satisfying the requirements of the tissues for blood, but which when produced more rapidly in response to drastic stimuli mediates the microvascular changes of the slow phase of inflammation locally, and of slowly-developing shock systemically. Induced histamine is, in effect, the "mirror image" of the glucocorticoids; this concept unifies many effects of these hormones in terms of a primary action on the capillaries. Consideration of other proposed hypotheses on mediators of autonomous microcirculatory behavior finds all to be unsatisfactory.

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