Synthesis of bis(aziridinyl)phosphinyl-N-hydroxyurethane derivatives as antineoplastic agents

1 February 1975

journal article
Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry

Vol. 18 (2) , 195-198
https://doi.org/10.1021/jm00236a019

Abstract

Several new "dual antagonists" were synthesized in which the 2,2-dimethyl (or ring C unsubstituted) aziridine phosphinyl function is linked to N-hydroxyurethane rather than the urethane moiety. Three of the new compounds showed very high activities against leukemia L1210 in mice.

Keywords

FUNCTION
AZIRIDINYL
BIS
PHOSPHINYL
HYDROXYURETHANE
LEUKEMIA
AZIRIDINE
ANTAGONISTS
ANTINEOPLASTIC

This publication has 0 references indexed in Scilit: