Characterization of the Activity of a Platelet Activating Factor Antagonist, CV-3988
Open Access
- 1 January 1987
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 44 (2) , 127-134
- https://doi.org/10.1254/jjp.44.127
Abstract
CV-3988 inhibited the vascular permeability increase induced by C16-PAF and C18-PAF in rat skin in a dose-dependent manner. The inhibition was shown to be specific and competitive with PAF on its receptor by the following observations: Parallel shift of the dose-response curve: Crossing of double reciprocal plots on the intersection of the ordinate; and No inhibition on other autacoids such as bradykinin, histamine, 5-hydroxytryptamine and LTC4. PAF-induced blood pressure fall in rats was also suppressed by pretreatment with CV-3988 selectively.This publication has 18 references indexed in Scilit:
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