Protamine-like Property of Compounds 48/80 and Stilbamidine and Their Action on Mast Cells.
- 1 July 1953
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 83 (3) , 455-457
- https://doi.org/10.3181/00379727-83-20384
Abstract
Compound 48/80 and stilbamidine produced both in vivo and in vitro bursting of rat mast cells. This phenomenon was observed with phase contrast microscopy as a rapid bubbling of cell surface. Both compounds presented an anti-heparin-like effect, and formed a precipitate in the presence of heparin, liquoid or cellulose sulphate. The in vivo and in vitro action of histamine liberators on mast cells suggests that these cells might be a source of histamine.Keywords
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- The identity and origin of the anticoagulant of anaphylactic shock in the dogThe Journal of Physiology, 1941
- Histamine Release from Blood Cells in Anaphylaxis in VitroScience, 1940