Hemoglobin switching: new insights

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Abstract
During the past year, many interesting advances have been made regarding molecular mechanisms controlling β-like globin gene switching. Throughout the β locus, cis-acting elements exist that are dynamically bound by trans-acting proteins, including transcription factors, coactivators, repressors, and chromatin modifiers. Characterization of transcription factors, their interaction with one another, and an ever-increasing role for chromatin structure in gene expression have enhanced understanding of the mechanism of globin gene switching. The studies reviewed here contribute new insights on the interplay between cis-acting elements, transcription factors, and chromatin modifiers that underlie globin gene switching during development.