Inhibition of influenza a virus replication by rifampicin and selenocystamine
- 1 January 1980
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 6 (2) , 169-174
- https://doi.org/10.1002/jmv.1890060210
Abstract
The effects of selenocystamine, an inhibitor of influenza virus RNA‐dependent RNA polymerase in vitro activity, and the antibiotic rifampicin were studied on influenza A/PR/8/34 (HON1) infection in embryonated eggs. Both drugs completely inhibited hemagglutinating and infective virus yields when added at relatively early times postinfection. Maximal inhibition was produced by apparently noncytotoxic concentrations of 50 m̈g of selenocystamine, or of 400 m̈g of rifampicin, per egg.Keywords
This publication has 21 references indexed in Scilit:
- An Inhibitor of the Particle-associated RNA-dependent RNA Polymerase of Influenza A and B VirusesJournal of General Virology, 1973
- In vivo and in vitro Suppression of Humoral and Cellular Immunological Response by RifampicinNature, 1970
- Rifampin Inhibition of H-1 Virus Infection in HamstersNature, 1970
- Specific Inhibition of Influenza Replication by α-AmanitinNature, 1970
- Vaccinia virus directed RNA and protein synthesis in the presence of rifampicinBiochemical and Biophysical Research Communications, 1969
- Rifampicin inhibits the Growth of Some Mammalian VirusesNature, 1969
- Action of rifamycins on RNA polymeraseBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1968
- Rifampicin: A New Orally Active RifamycinChemotherapy, 1966
- Effect on Myxovirus of Mitomycin C, Actinomycin D, and Pretreatment of the Host Cell with Ultra-Violet LightNature, 1965
- Participation of Deoxyribonucleic Acid in the Multiplication of Influenza VirusNature, 1962