Drug Metabolism and Variability among Patients in Drug Response
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- 26 May 2005
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 352 (21) , 2211-2221
- https://doi.org/10.1056/nejmra032424
Abstract
Differences in drug responsiveness are common, often leading to challenges in optimizing the dosage regimen for a particular patient. Recent advances provide a rational framework for understanding many interpatient differences in drug disposition and their clinical consequences. This article focuses on the cytochrome P-450 enzymes, a superfamily of microsomal drug-metabolizing enzymes that play an important role in oxidative drug metabolism.Keywords
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