Early Changes in Serum Progesterone, Estradiol and LH during Prostaglandin F -induced Luteolysis in Mares

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Abstract
Blood serum progesterone, estradiol and LH were quantified during luteolysis induced by prostaglandin F2α (PGF2α) in eight mares, and during a comparable time period in six control mares. In control mares progesterone averaged 9.2 ± 1.5 ng/ml when saline was injected and did not change more than 1.1 ng/ml on the average for the next 48 hours. However after PGF2α, progesterone decreased from 7.7 ± 1.1 ng/ml to .6 ± .1 ng/ml in 48 hours. The mares began estrus at 3.8 days on the average after PGF2α.. Luteolysis was accompanied by a transient increase in serum radioimmunoreactive progestogens; progestogens increased (P<.05) from 7.7 ± 1.1 to 10.3 ± 1.3 ng/ml at 10 min, then decreased (P<.05) to 4.8 ± .5 at 1 hr, 1.2 ± .4 at 24 hours. Meanwhile estradiol increased (P<.05) nearly twofold from 4.9 ± 1.1 to 8.0 ± 1.5 pg/ml at 1 hr after PGF2α treatment then decreased to less than 4.0 pg/ml at 8 hr and increased to 7.2 ± 2.0 pg/ml at 96 hours. Serum LH increased (P<.05) over two fold from 102 ± 24 to 237 ± 72 ng/ml at 30 min after PGF2α; LH then decreased (P<.01) to 95 ± 26 ng/ml at 8 hours. In the six mares treated with saline LH was more variable (P<.05) than after PGF2α but no consistent changes were observed. In conclusion transient changes in serum progestogens, LH and estradiol precede the decline in progesterone which follows PGF2α treatment in mares. Copyright © 1978. American Society of Animal Science . Copyright 1978 by American Society of Animal Science.

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