The Metabolism of Thiophen in the Rabbit and the Rat

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Abstract
1. In the rat thiophen (200-300 mg/kg), administered by stomach tube, was partly excreted unchanged in expired air (32%) and in faeces (< 1%) and partly (40%) in the urine as two mercapturic acids. Rabbits (150-225 mg/kg) excreted 38% as the same two mercapturic acids. 2. The mercapturic acid excreted in small quantities was shown to be 2-thienylmercapturic acid. 3. The other mercapturic acid was concluded on the basis of mass spectrometric measurements, infra-red spectroscopy and chemical properties to be a premercapturic acid, viz. 3-hydroxy-2,3-dihydro-2-thienylmercapturic acid.