AUTOIMMUNE THROMBOCYTOPENIC PURPURA AND PREGNANCY - NORMAL NEONATAL PLATELET COUNT IN THE PRESENCE OF CIRCULATING IGG AUTO-ANTIBODY IN THE MOTHER

  • 1 January 1984
    • journal article
    • research article
    • Vol. 26  (3) , 163-167
Abstract
Many pregnant women with AITP [autoimmune thrombocytopenic purpura] bear children with transient thrombocytopenia which is a potentially life threatening complication. Monitoring of IgG circulating platelet antibodies may help with the management of these women. The case of a pregnant woman with AITP was reported whose sera contained an IgG auto-antiplatelet demonstrated by the fluorescein labeled antiglobulin techniques. Steroids had a beneficial effect with a return to a normal of the mother''s platelet count but with no disappearance of the circulating antibody. Surprisingly the neonatal platelet count was normal and studies in the baby showed that the antibody had not crossed the placenta in detectable amounts. This case demonstrates the current inability to predict fetal thrombocytopenia and plan the mode of delivery.

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