The metabolism of 7- and 12-methylbenz[a]-anthracene and their derivatives

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Abstract
7-and 12-Methyl-benz[[alpha]]anthracene were converted by rat-liver homogenates into the corresponding hydroxymethyl derivatives, products that are probably the 8,9-dihydro-8,9-dihydroxy and 5,6-dihydro-5,6-dihydroxy derivatives, and a number of phenolic products. Both hydrocarbons were converted into glutathione conjugates; that from 7-methylbenz[[alpha]]anthracene was also formed, together with 5,6-dihydro-5,6-dihydroxy- and 5-hydroxy-benz[[alpha]]anthracene, from 5,6-epoxy-5,6-dihydro-7-methyl-benz[[alpha]]anthracene. 7- and 12-Hydroxymethylbenz[a]anthracene were converted into products that are probably 8,9-dihydro-8,9-dihydroxy derivatives, and into phenols. The preparation of a number of derivatives of the hydrocarbons is described. The oxidation of the hydrocarbons with lead tetra-acetate was investigated.