Measurement of Aromatisation by a Urine Technique Suitable for the Evaluation of Aromatase Inhibitorsin Vivo
- 1 January 1991
- journal article
- Published by Taylor & Francis in Journal of Enzyme Inhibition
- Vol. 4 (4) , 315-325
- https://doi.org/10.3109/14756369109030396
Abstract
By modification of a recently developed method for separation of radio-labelled urinary oestrogens we were able to separate oestrogen metabolites and measure their isotope ratios in urine following injections of [3H]delta 4-androstenedione and [14C]oestrone. This method provides a useful tool for studying in vivo aromatisation of delta 4-androstenedione into oestrone in breast cancer patients before and during treatment with aromatase inhibitors.Keywords
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