Antigenicity of clones of mouse prostate cells transformed in vitro

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Abstract
New cell‐surface antigens were detected on nineteen of twenty‐four malignant lines of 3‐methylcholanthrene (MCA)‐ or MCA‐epoxide‐transformed cells derived from cloned C3H mouse prostate cells. Exhaustive cross‐tests between lines derived from single control clones showed that in all but two lines these antigens were individually distinct and did not cross‐react. Eight spontaneously transformed cell lines were also examined but only two of these were antigenic. The remaining six lines appeared to be non‐immunogenic in syngeneic mice, although cell surface alloantigens were detectable. Non‐transformed cells were not immunogenic in syngeneic hosts, whether or not they had been treated with MCA.