Emesis as a Critical Problem in Chemotherapy

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Abstract
The achievements in cancer chemotherapy have been remarkable since World War II, when the modern era of antimetabolites and cytotoxic agents began. Although the rate of progress has been uneven, this is perhaps not surprising, given the lack of a unifying biochemical target for all cancers and the resulting need to test new drugs, singly or in combination, against many different tumor types. Clinical success, moreover, depends not only on finding drugs that are effective against specific cancers but also on finding ways to minimize their toxic side effects and thereby improve the therapeutic ratio. It is hardly an exaggeration . . .