Exchange Transfusion in the Treatment of Fulminating Hepatitis

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Abstract
ACUTE massive hepatic necrosis usually runs a short clinical course.1 The disease may terminate in death before the liver cells have an opportunity to regenerate and resume function. If the patient could be supported during the acute destructive phase until hepatic function returned, the chances for survival might be increased. In the belief that elevated levels of circulating ammonia and other unidentified toxins are critical2 , 3 intestinal nonabsorbable antibiotics have become a part of routine therapy.4 , 5 Massive doses of steroids are almost always employed in patients with fulminating hepatitis, in spite of the absence of any data confirming their efficacy.6 , 7 Recently, . . .

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