A DETERGENT-SOLUBLE EXTRACT OF VIRUS-INFECTED CELLS FREE FROM INFECTIOUS VIRUS PROTECTS MICE FROM LETHAL HERPES-SIMPLEX VIRUS-INFECTION
- 1 January 1980
- journal article
- research article
- Vol. 23 (4) , 199-204
Abstract
Lethal infection with herpes simplex virus types 1 (HSV-1) and 2 was effectively prevented by previous immunization with a detergent-soluble extract (DSE) of virus-infected cells, free from infectious virus without any adjuvant. This protective immunity seemed to last for at least 1 mo. Neutralizing antibodies were elicited in mice immunized with DSE, but at a lower level than in animals immunized with live or killed virus. DSE did not protect athymic nude mice from death by HSV-1 infection, suggesting that a T cell-mediated immune response plays a major role in the protection.This publication has 4 references indexed in Scilit:
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