TAMM-HORSFALL PROTEIN ABNORMAL LOCALIZATION IN RENAL-DISEASE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (5) , 550-555
Abstract
Interstitial deposits of periodic acid-Schiff positive fibrillar material were detected in a variety of diseases associated with tubulointerstitial pathology. This material was shown to be Tamm-Horsfall [TH] protein by immunofluorescent, immunochemical and EM studies. Prospective evaluation of 133 kidneys revealed deposits in 11%. These deposits included medullary cystic disease (50%), obstructive uropathy and vesicoureteral reflux (21%), and tubulointerstitial disease (29%). TH protein was also detected in Bowman''s space in 4 cases of obstructive uropathy. These deposits may result from severe tubular damage with release of TH protein fro its normal intracellular and intralumenal locations into the renal interstitium. The interstitial deposition of this sequestered protein may result in a continued inflammatory response and progressive renal damage.

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