Mechanisms of Curcumin- and EGF-Receptor Related Protein (ERRP)-Dependent Growth Inhibition of Colon Cancer Cells
- 1 July 2006
- journal article
- Published by Taylor & Francis in Nutrition and Cancer
- Vol. 55 (2) , 185-194
- https://doi.org/10.1207/s15327914nc5502_10
Abstract
Numerous dietary and pharmacological agents have been proposed as alternative strategies for treatment and prevention of colorectal cancer. Curcumin, an active ingredient of turmeric, that inhibits growth of malignant neoplasms, has a promising role in the prevention and treatment of colorectal cancer. EGF-R related protein (ERRP), a recently identified pan-erbB inhibitor, is a potential therapeutic agent for colorectal cancer. Here we examine whether curcumin together with ERRP will cause a greater inhibition of growth of colon cancer cells than either agent alone and the mechanisms of this inhibition. Human colon cancer HCT-116 or HT-29 cells were incubated with increasing doses of curcumin (up to 10 μM) or ERRP (up to 5 μg/ml), or a combination of both for 48 h. We observed that the cell growth inhibition and stimulation of apoptosis in response to the combinatorial treatment was significantly greater than that caused by either agent alone. These changes were associated with decreased activat...Keywords
This publication has 35 references indexed in Scilit:
- Antitumor Activity of Epidermal Growth Factor Receptor–Related Protein Is Mediated by Inactivation of ErbB Receptors and Nuclear Factor-κB in Pancreatic CancerCancer Research, 2006
- EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cellsBiochemical and Biophysical Research Communications, 2005
- Curcumin‐induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IκB kinase and nuclear factor κB activity and are independent of the B‐Raf/mitogen‐activated/extracellular signal‐regulated protein kinase pathway and the Akt pathwayCancer, 2005
- Epidermal Growth Factor Receptor–Related Protein Inhibits Cell Growth and Induces Apoptosis of BxPC3 Pancreatic Cancer CellsCancer Research, 2005
- RIα influences cellular proliferation in cancer cells by transporting RFC40 into the nucleusCancer Biology & Therapy, 2005
- Activation of PPARγ by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFRAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2005
- The growth hormone–insulin-like growth factor-I axis and colorectal cancerTrends in Molecular Medicine, 2001
- Effect of the Tyrosine Kinase Inhibitor STI571 in a Patient with a Metastatic Gastrointestinal Stromal TumorNew England Journal of Medicine, 2001
- The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic GrowthEndocrine Reviews, 2000
- Induction of NF-κB by the Akt/PKB kinaseCurrent Biology, 1999